Androgens and androgen receptors ar play a pivotal role in expression of the male phenotype several diseases such as androgen insensitivity syndrome ais and prostate cancer are associated . The ube2c protein half life of 6 hr in both lncap and abl cells suggests that it is ar dependent androgen independent up regulation ube2c transcription figures 4 5 6 and s14 rather than a more stable ube2c protein that contributes to its increased level and the increased growth of abl cells in the absence of androgen. The critical role of the androgen receptor ar in the development of prostate cancer is well recognized the transcriptional activity of ar is partly regulated by coregulatory proteins it has been suggested that these coregulators could also be important in the progression of prostate cancer the aim of this study was to identify coregulators whose expression is regulated by either the . The roles of androgen receptors and androgen binding proteins in nongenomic androgen actions it may ultimately contribute to regulation of transcription factor activity including mediation of the transcriptional activity of ar phosphorylation of steroid receptor coregulators has been found to influence their ability to interact with
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